Calcium antagonists in hypertension

Nitrendipine in severe hypertension. Satellite symposium on calcium antagonists.

We report the results of a multicenter trial in which nitrendipine, alone or in combination with a diuretic, a beta-blocker, or both, was administered to 114 patients with severe hypertension (greater than or equal to 115 mm Hg). Nitrendipine was titrated in doses of 5 to 30 mg b.i.d. If blood pressure was not controlled with nitrendipine alone, hydrochlorothiazide or propranolol or both were a...

Are calcium antagonists beneficial in diabetic patients with hypertension?

PURPOSE We analyzed the available data to assess the effects of calcium antagonists in hypertensive patients with diabetes mellitus. METHODS We performed a MEDLINE search of English-language articles published until April 2003, using the terms diabetes mellitus, hypertension or blood pressure, and therapy. Pertinent articles cited in the identified papers were also reviewed. We included prosp...

Atherosclerosis, calcium, and calcium antagonists.

Clinical pharmacology of calcium antagonists. Satellite symposium on calcium antagonists.

A new class of agents has been made available for the treatment of hypertension. These calcium antagonists have rapid bioavailability and dramatic antihypertensive effects through reduction of total peripheral resistance and the vascular resistance of the major target organs of the body. These changes are usually associated with unchanged cardiac output, preserved organ blood flows, maintained ...

Calcium antagonists and mortality risk in men and women with hypertension in the Framingham Heart Study.

BACKGROUND Several recent studies have suggested that calcium antagonist drugs, which are widely used for the treatment of hypertension, are associated with increased risk of cardiovascular disease. These studies have cast doubts on the long-term safety of calcium antagonists. OBJECTIVE To examine the association of calcium antagonist use with mortality in subjects with hypertension followed ...